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CAS No.: 2934-97-6

延胡索乙素 Catalog No. CSN16278

Synonyms: 延胡索乙素;DL-Tetrahydropalmatine;四氢巴马汀

Tetrahydropalmatine is an isoquinoline alkaloid mainly found in the genus Corydalis with analgesic effects. It antagonizes dopamine D1, and D2 receptors as well as actions at dopamine D3, alpha adrenergic and serotonin receptors, with Ki values of 124 nM and 388 nM for D1 and D2 dopamine receptors, respectively.

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生物活性

实验方案

技术信息

生物活性

描述Tetrahydropalmatine, one of the active components of rhizoma corydalis, exert several pharmacological effects, including anti-inflammatory, anti-tumor and analgesic activities. Tetrahydropalmatine did not exhibit any cellular toxicity up to 40 µM. Tetrahydropalmatine suppress lipid accumulation in 3T3-L1 cells and it inhibited pre-adipocyte differentiation in a concentration-dependent manner^[3]. Tetrahydropalmatine (80 mg/kg) may protect against ketamine-induced learning and memory impairment in mice via antioxidative, anti-inflammatory and anti-apoptotic mechanisms^[4].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02139761	Cocaine Use	Phase 2	Withdrawn(Study funding has no... more >>t been established) Collapse <<	June 2016	United States, Maryland ... more >> Maryland Psychiatric Research Center Catonsville, Maryland, United States, 21228 Collapse <<
NCT01631383	Cocaine Use	Phase 1	Completed	-	United States, Maryland ... more >> Maryland Psychiatric Research Center Catonsville, Maryland, United States, 21228 Collapse <<
NCT02118610	Schizophrenia	Not Applicable	Recruiting	December 2019	United States, Maryland ... more >> Maryland Psyciatric Research Center Recruiting Catonsville, Maryland, United States, 21228 Contact: Ann Kearns, BS 410-402-6854 akearns@mprc.umaryland.edu Collapse <<

参考文献

[1] Zhang X, Guan J, et al. Simultaneous determination of scutellarin and tetrahydropalmatine of Deng-yan granule in rat plasma by UFLC-MS/MS and its application to a pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Nov 15;971:126-32.
[2] Lin YY, Wang YP, et al. Plasma pharmacokinetics and lung distribution of tetrahydropalmatine after topical application of cold asthma recipe extract: Feishu (BL 13) versus Non-Feishu acupoint. J Ethnopharmacol. 2014 Apr 28;153(2):454-60.
[3] Piao GC, Liu GC, Jin XJ, Jin D, Yuan HD. Tetrahydropalmatine inhibits lipid accumulation through AMPK signaling pathway in 3T3‑L1 adipocytes. Mol Med Rep. 2017 Jun;15(6):3912-3918. doi: 10.3892/mmr.2017.6473. Epub 2017 Apr 12. PMID: 28440456.
[4] Ben Khelil M, Kamel M, Lahmar S, Mrabet A, Borsali Falfoul N, Hamdoun M. Death certificate accuracy in a Tunisian Emergency Department. Tunis Med. 2017 Jun;95(6):422-428. PMID: 29512798.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.8135 mL
- 14.0676 mL
- 28.1351 mL
- 5 mM
- 0.5627 mL
- 2.8135 mL
- 5.6270 mL
- 10 mM
- 0.2814 mL
- 1.4068 mL
- 2.8135 mL

技术信息

CAS号

2934-97-6

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C21H25NO4

运输

蓝冰

分子量

355.43

别名

延胡索乙素;DL-Tetrahydropalmatine;四氢巴马汀

溶解度

DMSO	14.0 mg/mL (39.4 mM)
Water	Insoluble
Ethanol	Insoluble

动物实验配方

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